Contrast In Dielectric Properties of Skin Lesions
Dielectric Spectroscopy on 146 Samples
A comprehensive dielectric spectroscopy study is conducted for the first time to characterize the ultra-wideband dielectric properties of freshly excised normal and malignant skin tissues obtained from skin cancer patients having undergone Mohs micrographic surgeries at Hackensack University Medical Center. Measurements are conducted using a precision slim-form open-ended coaxial probe in conjunction with a millimeter-wave vector network analyzer over the frequency range of 0.5-50 GHz. A one-pole Cole-Cole model is fitted to the complex permittivity dataset of each sample.
Statistically significant differences observed between normal skin and both cancer types (p < 0.05)
Peer-reviewed pre-clinical study:
A. Mirbeik. R. Ashinoff, and N. Tavassolian, “Ultra-Wideband Millimeter-Wave Dielectric Characteristics of Freshly-Excised Normal and Malignant Human Skin Tissues,” IEEE Trans. Biom. Eng., vol. 65, pp. 1320-1329, July 2018.
A. Mirbeik and N. Tavassolian, “Characterization and Validation of the Slim-form Open-Ended Coaxial Probe for the Dielectric Characterization of Biological Tissues at Millimeter-Wave Frequencies,” IEEE Microw. Compon. Lett., vol. 28, pp. 85-87, January 2018.
Synthetic Ultra-Wideband Imaging
An ultra-wide imaging frequency band (fL to fH) is divided into several adjacent sub-bands. Each is covered by a sub-band imaging element.
Selected Publications and Patent:
N. Tavassolian and A. Mirbeik, "Synthetic Ultra-Wideband Millimeter-Wave Imaging for Tissue Diagnostics," U.S. Patent Application No. 16/275,149.
A. Mirbeik, N. Tavassolian et al., "Synthetic Ultra-High-Resolution Millimeter-Wave Imaging for Skin Cancer Detection," IEEE Transactions on Biomedical Engineering, vol. 66, no. 1, pp. 61-71, Jan. 2019, doi: 10.1109/TBME.2018.2837102.
A. Mirbeik, R. Ashinoff and N. Tavassolian, "High-Contrast, Low-Cost, 3-D Visualization of Skin Cancer Using Ultra-High-Resolution Millimeter-Wave Imaging," IEEE Transactions on Medical Imaging, vol. 38, pp. 2188-2197, Sept. 2019.